Dimethyl Sulfoxide
Apexbio Technology LLC Linezolid(Synonyms: Zyvox, Zyvoxid, U-100766, PNU-100766, U-100766E, PNU100766, Linezolide), 10mM (in 1mL DMSO), CAS: 165800-03-3.
Linezolid (CAS 165800-03-3) is a synthetic oxazolidinone antimicrobial compound with broad-spectrum activity primarily against Gram-positive bacteria including multi-drug resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) vancomycin-resistant Enterococcus (VRE) and penicillin-resistant Streptococcus pneumoniae Linezolid inhibits bacterial protein synthesis by binding to the 23S ribosomal RNA of the 50S subunit thereby preventing formation of the functional 70S initiation complex In cell-free transcription-translation assays using E coli linezolid demonstrates an IC50 of approximately 1 8 mM Due to its pharmacokinetics and high oral bioavailability linezolid is widely utilized in clinical research related to complicated skin infections and bacterial pneumonia
Apexbio Technology LLC A-674563 552325-73-2 10mM (in 1mL DMSO)
A-674563 (CAS 552325-73-2) is a potent inhibitor of the serine/threonine kinase Akt1 (protein kinase B) with an IC50 of 14 nM It also demonstrates inhibitory activity against PKA and CDK2 with IC50 values of 16 nM and 46 nM respectively Akt regulates diverse cellular processes including proliferation apoptosis metabolism transcription and migration In cellular assays A-674563 suppresses proliferation in MiaPaCa-2 cells (EC50 0 4 M) reduces phosphorylation of GSK3 and MDM2 and induces G2-phase cell-cycle arrest and apoptosis in STS cells In mouse xenograft studies this inhibitor delays tumor growth and enhances paclitaxel efficacy illustrating its utility in oncology research
Apexbio Technology LLC Belinostat (PXD101) 414864-00-9 10mM (in 1mL DMSO)
Belinostat (PXD101) is a hydroxamic acid-based inhibitor targeting histone deacetylase (HDAC) enzymes Its mechanism involves the suppression of HDAC enzymatic activity leading to increased acetylation of histone proteins H3 and H4 within cells In biochemical assays using Hela cell extracts belinostat exhibits inhibitory activity against HDAC with an IC50 value of approximately 27 nM In tumor cell culture models belinostat induces cytotoxicity and represses cellular proliferation with reported IC50 values ranging roughly from 0 5 M to 10 M varying by cell type and origin making it suitable for research on epigenetic modulation in oncology specifically in studies of bladder prostate and related cancer cell lines
Apexbio Technology LLC Indirubin 479-41-4 10mM (in 1mL DMSO)
Indirubin (CAS 479-41-4) is a small molecule isolated from Danggui Longhui Wan a herbal medicine formulation It exerts anti-inflammatory effects primarily through the inhibition of interferon-gamma (IFN- ) production In vitro studies demonstrated that Indirubin suppresses IFN- secretion in human bone marrow mononuclear cells (HBL-38) and murine splenocytes without affecting cell proliferation In vivo administration of Indirubin reduced ear swelling in a mouse model of 2 4 6-trinitro-1-chlorobenzene (TNCB)-induced delayed-type hypersensitivity concomitant with decreased IFN- levels in lymphocyte cultures Indirubin is under clinical investigation for conditions such as psoriasis and acute promyelocytic leukemia
Apexbio Technology LLC Pomalidomide (CC-4047) 19171-19-8 10mM (in 1mL DMSO)
Pomalidomide (CC-4047) an immunomodulatory derivative structurally related to Thalidomide exhibits anti-tumor and anti-angiogenic properties Chemically the molecule is distinguished by additional amino substituent at the fourth position of the phthalimide ring and two extra oxy groups Its mechanism of action includes modulation of specific cytokines within the tumor microenvironment (TNF- IL-6 IL-8 VEGF) suppression of tumor cell proliferation and modification of host immune cell activity Pomalidomide is widely studied in biomedical research particularly in therapeutic exploration for hematologic malignancies such as multiple myeloma including relapsed or refractory disease states
Apexbio Technology LLC Resveratrol 501-36-0 10mM (in 1mL DMSO)
Resveratrol is a naturally occurring polyphenolic phytoalexin known to function as an activator of the NAD-dependent protein deacetylase SIRT1 Through SIRT1 activation resveratrol modulates downstream pathways implicated in cellular metabolism inflammation aging and tumorigenesis Commonly employed in biomedical research settings resveratrol serves as a molecular tool to explore the regulatory roles and signaling mechanisms involving sirtuin-mediated pathways Cellular assays have demonstrated resveratrol s inhibitory activity against multiple targets with reported IC50 values typically ranging from 20 to 50 M depending on cell type and experimental conditions Therefore resveratrol is widely utilized in vitro and in vivo to elucidate its roles in metabolic regulation inflammation responses cardiovascular function and cancer biology
Apexbio Technology LLC Ornidazole 16773-42-5 10mM (in 1mL DMSO)
Ornidazole a 5-nitroimidazole derivative exhibits antibacterial and antiprotozoal activities by interfering with DNA synthesis in anaerobic microorganisms through the reduction of its nitro group forming cytotoxic intermediates In experimental assays Ornidazole demonstrates inhibitory activity against diverse anaerobic bacterial strains including Bacteroides and Clostridium species and protozoan pathogens such as Giardia lamblia and Trichomonas vaginalis typically showing IC50 values ranging from micromolar to low millimolar concentrations This compound is widely utilized in microbiology and infectious disease research to elucidate anaerobic microbial drug sensitivity pathogen resistance mechanisms and protozoan infection biology
Apexbio Technology LLC AZD7762(Synonyms: AZD-7762, AZD 7762, 860352-01-8), 10mM (in 1mL DMSO), CAS: 860352-01-8.
AZD7762 (CAS No 860352-01-8) is an ATP-competitive inhibitor targeting the checkpoint kinases Chk1 and Chk2 regulatory enzymes activated upon DNA damage that control cell-cycle progression through phosphorylation of CDC25 phosphatases By competitively binding the ATP-binding pocket of Chk1 AZD7762 blocks Chk1-mediated phosphorylation of CDC25C exhibiting an IC50 of approximately 5 nM and Ki of 3 6 nM This inhibition prevents DNA damage-induced cell cycle arrest and interrupts DNA repair mechanisms promoting apoptosis in tumor cells Consequently AZD7762 acts as a chemosensitizing agent enhancing the cytotoxic effects of DNA-damaging therapies in oncology research
Apexbio Technology LLC Darifenacin HBr 133099-07-7 10mM (in 1mL DMSO)
Darifenacin HBr (CAS 133099-07-7) known as UK88525 is a selective antagonist of the M3 muscarinic acetylcholine receptor (mAChR M3) It demonstrates high binding affinity (pKi 8 9) toward M3 receptors which mediate smooth muscle contraction and glandular secretion in various tissues In vitro studies reveal that darifenacin acts as a substrate of the P-gp efflux transporter at the blood-brain and blood-ocular barriers In animal models darifenacin modulates bladder contractility and reduces bladder afferent nerve activity Clinically it is employed in research focusing on disorders involving abnormal detrusor muscle activity such as overactive bladder syndrome
Medchemexpress LLC Cimetidine sulfoxide | 54237-72-8 | 97.0% | C10H16N6OS | 10MG
Cimetidine sulfoxide is the sulfoxide metabolite of cimetidine provided for research and analytical applications (CAS 54237-72-8). Supplied as a research-grade solid, it is used as a reference standard in studies of histamine H2-receptor antagonists, drug metabolism, and analytical method development.
- High-purity reference standard suitable for analytical assays.
- Useful for metabolic and pharmacokinetic studies.
- Available in small milligram pack sizes for research use.
- Documentation available: COA, SDS, and handling instructions.
- Stable solid form for storage and long-term use.
Apexbio Technology LLC TG003 300801-52-9 10mM (in 1mL DMSO)
TG003 (CAS 300801-52-9) is a selective inhibitor targeting the Cdc2-like kinase (Clk) family and casein kinase 1 (CK1) Specifically it demonstrates notable potency against mClk1 mClk2 and mClk4 with IC50 values of approximately 20 nM 200 nM and 15 nM respectively TG003 competitively binds with ATP at Clk1 modulating Clk-mediated phosphorylation of serine/arginine-rich (SR) proteins involved in alternative mRNA splicing Studies using HeLa cellular extracts and animal models have shown that TG003 alters splice site selection and pre-mRNA processing suggesting potential utility for investigating RNA splicing regulatory mechanisms
Apexbio Technology LLC A-740003(Synonyms: A740003, A 740003, P2X7 Receptor Antagonist A-740003, A-740003 P2X7 Antagonist, 861393-28-4), 10mM (in 1mL DMSO), CAS: 861393-28-4.
A-740003 (CAS 861393-28-4) is a selective and competitive antagonist targeting the P2X7 receptor a member of the ATP-gated ionotropic P2X receptor family involved in immune cell signaling cytokine secretion apoptosis and cellular proliferation The antagonist displays IC50 values of 18 nM and 40 nM against mouse and human P2X7 receptors respectively In human THP-1 macrophage-like cells A-740003 inhibits pore formation assessed by Yo-Pro uptake assay (IC50 92 nM) and reduces interleukin-1 secretion (IC50 156 nM) This compound is employed in research investigating P2X7-mediated inflammatory pathways and neuropathic pain mechanisms
Apexbio Technology LLC Fenretinide 65646-68-6 10mM (in 1mL DMSO)
Fenretinide (4-HPR) is a synthetic retinoic acid analog which acts primarily through inhibition of focal adhesion kinase (FAK) and modulation of related signaling cascades Fenretinide induces apoptosis in various tumor cell lines such as prostate ovarian cervical endometrial breast small-cell lung carcinoma and malignant hematopoietic cells Mechanistically Fenretinide promotes apoptotic cell death through reactive oxygen species (ROS)-mediated DNA fragmentation and disrupts tumor cell migration and invasion via interference with the FAK/AKT/GSK3 signaling axis and destabilization of -catenin Fenretinide is frequently utilized as a chemopreventive agent in oncology research particularly for investigating mechanisms of growth inhibition and cell migration suppression
Apexbio Technology LLC PKI-402 1173204-81-3 10mM (in 1mL DMSO)
PKI-402 (CAS 1173204-81-3) is an ATP-competitive inhibitor targeting class I PI3Ks (PI3K ) with IC50 values of 1 nM 7 nM 16 nM and 14 nM respectively PI3Ks are enzymes central to the PI3K/Akt/mTOR signaling pathway impacting cellular proliferation survival differentiation and migration processes critically involved in cancer progression PKI-402 reduces cell growth and phosphorylation of PI3K/mTOR downstream signaling proteins in human tumor cell lines including breast glioma pancreatic and non-small cell lung cancers In xenograft mouse models (MDA-MB-361) PKI-402 administration suppresses Akt phosphorylation triggers apoptosis (PARP cleavage) and inhibits tumor growth highlighting its significance for cancer biology research
Medchemexpress LLC Toltrazuril sulfoxide | 69004-15-5 | MFCD10567359 | 99.6% | C18H14F3N3O5S | 10MG
Toltrazuril sulfoxide is an analytical standard corresponding to the short-lived sulfoxide metabolite of toltrazuril. It is intended for research and analytical applications, including metabolic studies, method development, and quantitative analysis of toltrazuril metabolites.
- Analytical standard suitable for metabolic and pharmacokinetic studies.
- High purity (99.6%) for reliable analytical results.
- Provided in small pack sizes for trace-level assays and method validation.
- Compatible with LC-MS and other chromatographic detection methods.
- Stable solid form for routine storage and handling.