Dimethyl Sulfoxide
Apexbio Technology LLC Prilocaine 721-50-6 10mM (in 1mL DMSO)
Prilocaine (CAS 721-50-6) is a local anesthetic molecule categorized within the amino amide class Its primary pharmacological mechanism involves reversible blockade of voltage-gated sodium channels in neuronal membranes thereby inhibiting action potential propagation and sensory nerve impulse conduction Due to its sodium channel-blocking profile prilocaine is commonly investigated in biomedical research examining reversible neural inhibition pain modulation pathways and sensory signal transmission mechanisms
Apexbio Technology LLC Azaguanine-8 134-58-7 10mM (in 1mL DMSO)
Azaguanine-8 (CAS 134-58-7) is a synthetic purine analog utilized in biomedical research due to its antineoplastic properties Structurally similar to guanine Azaguanine-8 exerts its biological activity by competitively interfering with guanine metabolism subsequently disrupting nucleic acid synthesis and cellular replication pathways Through this mechanism the compound demonstrates inhibitory effects on cell proliferation making it a valuable tool in investigating nucleic acid metabolism and cancer biology in preclinical studies
Apexbio Technology LLC LY2584702 1082949-67-4 10mM (in 1mL DMSO)
LY2584702 (CAS 1082949-67-4) is an orally bioavailable ATP-competitive inhibitor selectively targeting p70 S6 kinase (p70S6K) a serine/threonine kinase downstream of the PI3K/Akt/mTOR signaling cascade By inhibiting p70S6K activity LY2584702 effectively suppresses phosphorylation of ribosomal protein S6 (S6) thereby modulating protein translation LY2584702 exhibits potent inhibition of p70S6K (IC50 4 nM) and effectively reduces phosphorylated S6 levels in HCT116 colorectal cancer cells (IC50 between 0 1-0 24 M) Notably LY2584702 demonstrated anticancer activity in preclinical xenograft models supporting its role in targeted cancer research and therapeutic development
Apexbio Technology LLC BV6 1001600-56-1 10mM (in 1mL DMSO)
BV6 (CAS 1001600-56-1) is a selective inhibitor targeting the inhibitor of apoptosis protein (IAP) family The IAP family includes proteins such as XIAP c-IAP1 and c-IAP2 that regulate programmed cell death pathways BV6 induces apoptosis and sensitizes cancer cells to chemotherapeutic agents and radiation by decreasing expression levels of IAPs including XIAP and c-IAP1 In vitro treatment with BV6 exhibited an IC50 of 7 2 M in H460 non-small cell lung carcinoma cells and enhanced their response to radiation BV6 is employed in research exploring cancer cell apoptosis modulation and therapeutic resistance
Apexbio Technology LLC Atglistatin 1469924-27-3 10mM (in 1mL DMSO)
Atglistatin (CAS 1469924-27-3) is a small-molecule inhibitor selective for adipose triglyceride lipase (ATGL) an enzyme that catalyzes the rate-limiting step in triglyceride hydrolysis releasing fatty acids from cellular triglyceride stores Atglistatin inhibits ATGL activity competitively with an IC50 of 0 7 M and Ki of 355 nM In mouse white adipose tissue lysates atglistatin decreased triglyceride hydrolase activity by approximately 78% effectively reducing fatty acid and glycerol release This compound serves as a valuable tool in lipid metabolism and metabolic disease research
Apexbio Technology LLC Halcinonide 3093-35-4 10mM (in 1mL DMSO)
Halcinonide (CAS 3093-35-4) is a potent synthetic corticosteroid widely utilized in biomedical research as a topical anti-inflammatory agent Mechanistically halcinonide exerts biological effects primarily through activation of glucocorticoid receptor pathways subsequently modulating gene transcription and suppressing the release of inflammatory mediators Owing to its robust corticosteroid receptor agonism and pronounced anti-inflammatory properties this compound frequently supports investigations into inflammatory dermatological conditions and glucocorticoid signaling pathways
Apexbio Technology LLC Sirtinol 410536-97-9 10mM (in 1mL DMSO)
Sirtinol (CAS 410536-97-9) is a small-molecule inhibitor targeting class III histone deacetylases (HDAC) specifically the NAD-dependent deacetylases SIRT1 and SIRT2 In MCF-7 human breast cancer cells sirtinol exhibits inhibitory activity against cell proliferation with IC50 values of 48 6 M (24 h) and 43 5 M (48 h) Mechanistically sirtinol reduces SIRT1 expression inducing acetylation of p53 and downregulating cell-cycle proteins such as cyclin B1 cyclin D1 CDK2 and CDK6 leading to G1-phase arrest apoptosis and autophagy This molecule serves as a valuable research tool in epigenetic studies and cancer biology investigations
Apexbio Technology LLC C646 328968-36-1 10mM (in 1mL DMSO)
C646 (CAS 328968-36-1) is a small molecule pyrazolone derivative that functions as a selective competitive inhibitor of the histone acetyltransferase (HAT) activity of p300 It binds to the active site of p300 forming hydrogen bonds with residues Thr1411 Tyr1467 Trp1466 and Arg1410 C646 demonstrates a Ki of 400 nM and an IC50 of 1 6 M against p300 and also inhibits several p300 point mutants By specifically targeting p300-mediated protein acetylation C646 serves as a valuable research tool in studies investigating histone modification and gene transcription regulation
Apexbio Technology LLC Elesclomol (STA-4783) 488832-69-5 10mM (in 1mL DMSO)
Elesclomol (STA-4783 CAS 488832-69-5) is a small molecule identified through phenotype-based screens for apoptotic activity which induces apoptosis in cancer cells by elevating intracellular reactive oxygen species (ROS) Its primary cellular target is mitochondrial electron transport disruption of which results in rapid accumulation of oxidative stress exceeding adaptive thresholds and ultimately triggering apoptotic cell death Elesclomol demonstrates antitumor activity across diverse human tumor xenograft models and is currently studied as an investigational anticancer compound capable of extending progression-free survival
Apexbio Technology LLC MK-8245 1030612-90-8 10mM (in 1mL DMSO)
MK-8245 (CAS 1030612-90-8) is a potent liver-selective small molecule inhibitor of stearoyl-CoA desaturase (SCD) SCD1 catalyzes fatty acid desaturation and represents a target for treating type II diabetes obesity dyslipidemia and other metabolic disorders MK-8245 demonstrates strong inhibitory activity against rat mouse and human SCD1 with an IC50 of approximately 1 nM and displays liver-specific tissue distribution mediated by organic anion transporting polypeptides (OATPs) Animal studies revealed MK-8245 reduces blood glucose levels and hepatic triglycerides dose-dependently supporting its application in metabolic disease research
Apexbio Technology LLC Tolcapone 134308-13-7 10mM (in 1mL DMSO)
Tolcapone (CAS 134308-13-7) is an orally bioavailable reversible small-molecule inhibitor targeting catechol-O-methyltransferase (COMT) Acting through competitive inhibition tolcapone structurally incorporates a catechol moiety with electron-withdrawing substituents facilitating anionic formation that binds potently to COMT s catalytic site (reported IC50 of approximately 36 nM in rat liver assays) By competitively occupying this active site tolcapone prevents the enzymatic methylation of endogenous catechols such as levodopa thus prolonging levodopa s bioavailability Tolcapone is primarily investigated as adjunctive therapeutic agent in Parkinson s disease research enabling reduced levodopa dosage while enhancing symptomatic control
Apexbio Technology LLC BIRB 796 (Doramapimod) 285983-48-4 10mM (in 1mL DMSO)
BIRB 796 (Doramapimod CAS 285983-48-4) is a potent inhibitor of human p38 mitogen-activated protein kinase (MAPK) which modulates the signaling pathways associated with inflammatory cytokine production It demonstrates significant inhibition of TNF- release (EC50 18 nM) in THP-1 cells In animal models oral administration reduces LPS-induced TNF- synthesis and ameliorates collagen-induced arthritis severity Clinically however trials for Crohn s disease showed no superiority over placebo BIRB 796 serves as a valuable research tool in inflammation and cytokine signaling studies
Apexbio Technology LLC Verapamil HCl 152-11-4 10mM (in 1mL DMSO)
Verapamil HCl (CAS 152-11-4) is a small molecule belonging to the phenylalkylamine class characterized by selective inhibition of L-type calcium channels By blocking calcium influx through voltage-dependent calcium channels verapamil modulates intracellular calcium signaling affecting smooth muscle contraction cardiac electrophysiology and neurotransmitter release It is frequently utilized in research to investigate calcium channel-related physiological processes cardiovascular function and cellular signaling mechanisms
Apexbio Technology LLC Lonidamine 50264-69-2 10mM (in 1mL DMSO)
Lonidamine (AF-1890) is a cell metabolism inhibitor targeting mitochondrial pyruvate carrier and hexokinase exhibiting inhibitory activity with a Ki value of approximately 2 5 M Through these targets it disrupts glycolytic metabolism by impairing aerobic glycolysis processes common in tumor cells Researchers utilize Lonidamine primarily to investigate metabolic pathways implicated in cancer cell energy production alterations in mitochondrial functions and related metabolic disorders Additionally Lonidamine is employed experimentally in studies examining mitochondrial dysfunction-associated conditions and inflammatory responses including pulmonary fibrosis